A study of patients taking the acne drug Accutane shows that Accutane is worse for the heart than originally thought. The study found that an abnormally high percentage of individuals taking the drug exhibited elevated levels of cholesterol and triglycerides. More than one in ten study participants also displayed abnormal liver tests.
The study, published by Archives of Dermatology in 2006, involved an analysis of the laboratory tests of 13,722 patients who were members of the Kaiser Permanente health plan in California. The patients studied had received Accutane treatment between March of 1995 and September of 2002. All patients involved in the analysis were between the ages of 13 and 50.
Initial findings of the study indicated that 44 percent of patients developed elevated levels of triglycerides while taking the drug. Additionally, 31 percent of the patients displayed elevated cholesterol levels. These percentages are significantly higher than those referenced in the original package insert. In addition to detecting elevated triglyceride and cholesterol levels, the study found that 11 percent of patients exhibited high levels of liver enzymes. Lab tests for these patients were normal prior to taking Accutane.
Accutane is the brand name for isotretinoin, which is prescribed as an aggressive treatment for severe acne. The drug has been linked to a host of physical and mental health disorders, including Inflammatory Bowel Disease (IBD), ulcerative colitis, Crohn’s diseases, adult depression, and birth defects in infants whose mothers took the drug during pregnancy. Because of the health risks associated with Accutane use, the U.S. Food and Drug Administration (FDA) required patients and doctors to document their use of the drug in a drug registry maintained by the FDA.
While abnormally high cholesterol and triglyceride levels do not necessarily mean that a patient is destined to have a heart attack, such elevations can be a contributing factor to heart disease. The study highlights the importance of monitoring levels of cholesterol and triglycerides, particularly in patients currently taking Accutane. The long term effects of taking Accutane are not explored by the study, but lab results did indicate that the cholesterol and triglyceride levels returned to normal in the majority of patients after use of the drug was discontinued.
This article should not be construed as legal advice. It was not written by an attorney.
If you are interested in speaking with an Accutane lawyer please contact the law firm of Goldberg & Osborne in Phoenix, AZ.